✦ LIBER ✦

Reactions of Hydantoin and Succinimide Anticonvulsants with Dimethyl Ether Ions in a Quadrupole Ion Trap Mass Spectrometer

✍ Scribed by Shen, Jim Xiangxin; Brodbelt, Jennifer

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 878 KB
Volume: 31
Category: Article
ISSN: 1076-5174
DOI: 10.1002/(sici)1096-9888(199612)31:12<1389::aid-jms437>3.0.co;2-4

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✦ Synopsis

The analysis of hydantoin and succinimide anticonvulsants was carried out using techniques of chemical ionization and collision activated dissociation (CAD) in a quadrupole ion trap. Dimethyl ether was used as the chemical ionization reagent gas to generate [M + HI+ and IM + 13)' products, with the objective of determining whether the protonation and methylene substitution reactions occurred at the same site and whether the products provided the same structural information. CAD, including MS3, SWIFT double resonance experiments and deuteriumlabeling studies suggest that protonation occurs on a nitrogen atom or carbonyl oxygen while methylene substitution occurs predominantly on the phenyl substituents. Both [ M + H ] + and [ M + 131 + ions dissociate by similar pathways in which typically the attached proton or methylene group remains a spectator.

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