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Reactions of copper complexes with oxygen radicals generated by human neutrophils

✍ Scribed by Haseloff, Reiner F. ;Gruner, Stefan ;Wischnewsky, Gerd G.

Publisher
John Wiley and Sons
Year
1992
Weight
372 KB
Volume
7
Category
Article
ISSN
0884-3996

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✦ Synopsis

The intensity of the chemiluminescence of unstimulated human neutrophils in the presence of luminol was used to investigate the effects of low-molecular-weight copper complexes at the cellular level. In different models (superoxide dismutase mimetic activity, inhibition of haematoporphyrin derivative/light-induced lysis of cells), the biological activity of the complexes exceeded the activity of the ligands alone.

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