Reactions of Artemisinin and Arteether with Acid: Implications for Stability and Mode of Antimalarial Action
β Scribed by Drew, Michael G. B.; Metcalfe, John; Dascombe, Michael J.; Ismail, Fyaz M. D.
- Book ID
- 118235258
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 225 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0022-2623
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In CH& in the presence. of bcnzylamine, artemisinin transfers an oxyg~l atom from the intermediate open hydropcroxide to tertiary amines to form N-ox&s and N-beuzyl-1 1 -azadesoxyartemisinin Basecatalyzed side reactions interfere with the correspondin reaction involving clibydroartemisinin. The reac