Reactions of 2-Monosubstituted 3-Amino-2H-azirines with NH-Acidic Heterocycles
✍ Scribed by José M. Villalgordo; Anthony Linden; Heinz Heimgartner
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- German
- Weight
- 665 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0018-019X
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📜 SIMILAR VOLUMES
Recently, we tried to establish the proposed reaction mechanism by proceeding the reaction at lower temperature and with differently substituted 3-amino-7'2-azirines 1 in order to isolate the postulated intermediate C. ## 4, Determined by potentiomemc titration.
Reaction of 2,2-dialkyl-3-(dimethylamino)-2H-azirines la and l b with 2.3-pyridinedicarboximide (4) in MeCN or DMF at room temperature yielded two regioisomeric tricyclic 1:l adducts, the azacyclols 11/12 and 16/17, respectively (Schemes 3 and 4 ) . The structure of 12 was established by X-ray cryst