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Reactions of 1,4-Benzodiazepinic N-Nitrosoamidines with Tosylmethyl Isocyanide: A Novel Synthesis of Midazolam.

✍ Scribed by Carlos del Pozo; Alberto Macias; Eduardo Alonso; Javier Gonzalez


Publisher
John Wiley and Sons
Year
2005
Weight
27 KB
Volume
36
Category
Article
ISSN
0931-7597

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One-Step Synthesis of Dialkyl 2-[(4-Meth
✍ Abdolali Alizadeh; Hassan Masrouri; Sadegh Rostamnia; Farnaz Movahedi 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 German ⚖ 61 KB

## Abstract The reactive 1 : 1 adducts in the reaction between Ph~3~P and dialkyl acetylenedicarboxylates have been trapped with ‘tosylmethyl isocyanide’ (TsMIC; **1**) to yield dialkyl 2‐[(4‐methylphenyl)sulfonyl]‐1__H__‐pyrrole‐3,4‐dicarboxylates **3** (__Scheme 1__). The structures of the highly