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Diastereo- and Enantioselective Synthesis of Novel β-Lactam-Containing 1,4-Benzodiazepines through a Ketene−Imine Cycloaddition Reaction

✍ Scribed by Carlos del Pozo; Alberto Macías; Fernando López-Ortiz; Miguel Ángel Maestro; Eduardo Alonso; Javier González


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
224 KB
Volume
2004
Category
Article
ISSN
1434-193X

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[2+2] Cycloaddition Reactions of Imines
✍ Giuseppe Cremonesi; Piero Dalla Croce; Concetta La Rosa 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 German ⚖ 190 KB

## Abstract Unsymmetric cyclic ketenes were generated from __N__‐acyl‐1,3‐thiazolidine‐2‐carboxylic acids **1a**–**c** by means of __Mukaiyama__'s reagent, and then reacted with imines **2a**–**c** to the new, isomeric spiro‐__β__‐lactams **3** and **4** __via__ [2+2] cycloaddition (__Staudinger__