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Reactions between acids and thiourea: Part I. The formation of amides from acids and thiourea

✍ Scribed by Aziz-Ur Rahman; Miguel A. Medrano; O. P. Mittal

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
224 KB
Volume
79
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

A method for the preparation of acid amides by heating an equimolecular mixture of acid and thiourea, is described. The method has been successfully applied to aliphatic mono‐ and di‐basic acids, aryl‐aliphatic acids as well as benzoic acid. The yield has been found to be dependent upon the relative volatility of the acid employed for the reaction. Best yields have been obtained with aryl‐aliphatic acids. The mechanism of amide formation from acid and thiourea, based upon the intermediate addition of carboxylic acid to thiocyanic acid, the latter formed by the decomposition of thiourea, is suggested and an electronic representation of the mechanism is given.

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