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Reaction of α-amidoalkylphenyl sulfones with Reformatsky reagents. A new entry to β-amino esters

✍ Scribed by Tiziana Mecozzi; Marino Petrini

Book ID
104210108
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
113 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The reaction of Reformatsky reagents with α-amidoalkylphenyl sulfones proceeds in dichloromethane at room temperature leading to the synthesis of the corresponding β-amino esters in good yields. The procedure presents syn stereoselectivity and can be also extended to Reformatsky reagents based on γ-bromocrotonates.

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