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Reaction of pyrrolo[2,1-c][1,4]benzodiazepine-2,5,11-triones with phosphorus oxychloride

✍ Scribed by Ahmed Kamal; David E. Thurston

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
139 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis

Reaction of pyrrolo[Z,l-cl[1,4lbenzodiazepine-2,5,11-triones of type 3a_c with phosphorus oxychloride affords chloroalkenes of type 4a-c instead of the expected chloroimidates (6a-c). The pyrrolo[Z,l-c][1,4]benzodiazepine (PBD) family of antitumor antibiotics'

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Facile synthesis of pyrrolo[2,1-c][1,4]b
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## Abstract magnified image Efficient synthesis of biological important pyrrolo[2,1‐__c__][1,4]benzodiazepine‐5,11‐dione dimer linked through the C‐2 positions by fumarate group is described.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v