Reaction of nitriles under acidic conditions: a novel, direct formation of condensed 4-chloropyrimidines

✍ Scribed by C.J. Shishoo; M.B. Devani; V.S. Bhadti; S. Ananthan; G.V. Ullas

• Book ID: 104219946
• Publisher: Elsevier Science
• Year: 1983
• Tongue: French
• Weight: 108 KB
• Volume: 24
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)85969-9

✦ Synopsis

An unnsual fomation of condensed 4-chloropyrimidines in the reaction of o-aminonitriles with halogenoacetonitriles in the presence of dry hydrogen chloride gas is described. We have earlier described 192 a facile one-pot synthesis of fused pyrimidines by the reaction of nitriles with o-eminocarbonyl compounds in the presence of dry hydrogen