Condensation Reactions and Formation of Amides, Esters, and Nitriles Under Hydrothermal Conditions
β Scribed by Rushdi, Ahmed I.; Simoneit, Bernd R.T.
- Book ID
- 124077718
- Publisher
- Mary Ann Liebert
- Year
- 2004
- Tongue
- English
- Weight
- 471 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1531-1074
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An unnsual fomation of condensed 4-chloropyrimidines in the reaction of o-aminonitriles with halogenoacetonitriles in the presence of dry hydrogen chloride gas is described. We have earlier described 192 a facile one-pot synthesis of fused pyrimidines by the reaction of nitriles with o-eminocarbonyl
The development of the highly diastereoselective catalytic synthesis of glycidic acid derivatives via Darzens reaction is described. The reaction of a-chloroesters and amides with aromatic aldehydes smoothly proceeds in the presence of a quaternary ammonium salt as a phase-transfer catalyst to give