Reaction of guanosine, 2′-deoxyguanosine and guanosine-5′-monophosphate with glucose
✍ Scribed by Thomas Knerr; Stefan Ochs; Theodor Severin
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 438 KB
- Volume
- 256
- Category
- Article
- ISSN
- 0008-6215
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📜 SIMILAR VOLUMES
The purine moiety of guanosine is known to react with epoxides and P-propiolactone at the 7-nitrogen (1, 2), with N-acetoxy-N-Z-fluorenylacetamide at the B-carbon (3); and reversibly with formaldehyde (4, 5, 6) at the amino group of the 2-position, and with 1,2-dicarbonyl
The reaction of guanosine with glucose, glucose 6-phosphate or ribose in the presence of propylamine leads to the formation of several guanosine derivatives. During this process sugar degradation products are attached to the amino group of the guanosine residue. N2-(I-Carboxy-3,4-dihydroxybutyl)-gua
## Abstract Semiempirical molecular orbital studies were performed on 5′‐guanosine monophosphate in its various states of base and phosphate ionization (employing the extended Hückel method) and on guanosine protonated on N‐3 and on N‐7 (employing CNDO/2). Semiempirical potential energy calculation