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Reaction of Barbituric, 2-Thiobarbituric Acids and Their Derivatives with 2-Carboxybenzaldehyde and Opianic Acid: Synthesis and Tautomerism of 5-(3'-Oxo-1',3'-dihydroisobenzofuran-1'-yl)barbituric Acids and Their 2-Thio Analogs

✍ Scribed by K. A. Krasnov; V. G. Kartsev; E. E. Santarovich


Book ID
110392116
Publisher
Springer US
Year
2002
Tongue
English
Weight
166 KB
Volume
38
Category
Article
ISSN
0009-3122

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Synthesis of 5-(functionalized acyl)-1,3
✍ Hanafi H. Zoorob; Mohamed A. Ismail; Lucjan Strekowski πŸ“‚ Article πŸ“… 2001 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 53 KB

## Abstract A sodium derivative of 1,3‐dimefhylbarbituric acid or 1,3‐diethyl‐2‐thiobarbituric acid undergoes an efficient monoacylation at C5 by the reaction with ω‐chloroalkanoyl chloride or diacid dichloride in the presence of pyridine in tetrahydrofuran. A nucleophilic displacement of the chlor