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Synthesis and alkaline decomposition of 5-alkyl-5-(1-methyl-3-oxobutyl)barbituric and 2-thiobarbituric acid derivatives

โœ Scribed by Carroll, F. Ivy; Philip, Abraham


Book ID
127267794
Publisher
American Chemical Society
Year
1971
Tongue
English
Weight
341 KB
Volume
14
Category
Article
ISSN
0022-2623

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Synthesis of 5-(functionalized acyl)-1,3
โœ Hanafi H. Zoorob; Mohamed A. Ismail; Lucjan Strekowski ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 53 KB

## Abstract A sodium derivative of 1,3โ€dimefhylbarbituric acid or 1,3โ€diethylโ€2โ€thiobarbituric acid undergoes an efficient monoacylation at C5 by the reaction with ฯ‰โ€chloroalkanoyl chloride or diacid dichloride in the presence of pyridine in tetrahydrofuran. A nucleophilic displacement of the chlor