Reaction of Amides with Nitric Oxide (NO). -The reaction of a variety of amides (13 examples) with NO is studied in detail in order to get insight in nitrosation reactions of amides in biological media. The reaction is accelerated by addition of oxygen and does not proceed in protic solvents sugges
Reaction of amides with nitric oxide (NO)
✍ Scribed by Takashi Itoh; Kazuhiro Nagata; Yûji Matsuya; Michiko Miyazaki; Akio Ohsawa
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 215 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Amides were allowed to react with nitric oxide in aprotic and non-ethereal solvents to give the corresponding N-nittoso derivatives. The reaction was accelerated by addition of oxygen. The solvent effect revealed that the reaction did not proceed in the presence of protic media.
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## Abstract Free radicals generated from UV irradiation of simple aliphatic amides in anaerobic and nitric oxide (NO)‐saturated liquid mixtures or solutions gave EPR spectra of nitroxides. The application of isotopic effects to EPR spectra and the generation of radicals by transient radical attack
Reaction of Nitric Oxide with Amines. -NO and NO/O2, respectively, are found to be useful reagents for the aromatization of Hantzsch dihydropyridines (→ (II)) and deamination of aromatic amines (→ (VI)). -