Reaction of pyrrolo[Z,l-cl[1,4lbenzodiazepine-2,5,11-triones of type 3a\_c with phosphorus oxychloride affords chloroalkenes of type 4a-c instead of the expected chloroimidates (6a-c). The pyrrolo[Z,l-c][1,4]benzodiazepine (PBD) family of antitumor antibiotics'
Reaction of 5-Chloro-2-hydroxybenzophenone with Phosphorus Oxychloride and Related Reactions.
โ Scribed by A. G. Pinkus; Tsung C. Chang; Lily Y. C. Meng
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 18 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The reactions of four equivalents of heterocyclic aryllithium compounds with phosphorus trichloride or phosphorus oxychloride gave symmetrical heterocyclic biaiyls in good yields. A similar coupling was found in the reactions of three equivalents of the lithi u m compounds with thionyl chloride.
The kinetics of the reaction of 2-chloro-3-nitropyridine (ortho-like) and 2-chloro-5-nitropyridine (para-like) with a series of aryloxide ions were studied in methanol at different temperatures. Plots of DH โ versus DS โ for both reactions gave good straight lines with isokinetic temperatures of 168