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Reaction of 2′-deoxyguanosine with glucose

✍ Scribed by S. Ochs; T. Severin

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
415 KB
Volume
266
Category
Article
ISSN
0008-6215

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✦ Synopsis

Glucose reacts with 2'-deoxyguanosine under physiological conditions to give the diastereomeric purine substituted trihydroxy-a-amino hexanoic acids 4 as main products. Hydrolysis of 4 leads to the guanine derivatives 6 which have been synthesized by an independent route.

📜 SIMILAR VOLUMES

Reaction of 2′-Deoxyguanosine with Glyce
Reaction of 2′-Deoxyguanosine with Glyceraldehyde
✍ Ochs, Stefan ;Severin, Theodor 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 277 KB

## Abstract Reaction of 2′‐deoxyguanosine with glyceraldehyde under physiological conditions leads to the formation of ammonium 2‐[9‐(2‐deoxy‐β‐D‐ribofuranosyl)‐6,9‐dihydro‐6‐oxo‐1__H__‐purin‐2‐ylamino]propionate (8). The same substance can be detected in 2′‐deoxyguanosine/glucose reaction mixtures

The reaction of guanosine and deoxyguano
The reaction of guanosine and deoxyguanosine with glycidaldehyde
✍ B.M. Goldschmidt; T.P. Blazej; B.L. Van Duuren 📂 Article 📅 1968 🏛 Elsevier Science 🌐 French ⚖ 201 KB

The purine moiety of guanosine is known to react with epoxides and P-propiolactone at the 7-nitrogen (1, 2), with N-acetoxy-N-Z-fluorenylacetamide at the B-carbon (3); and reversibly with formaldehyde (4, 5, 6) at the amino group of the 2-position, and with 1,2-dicarbonyl