Reaction of 2-acylamino-3,3-dichloroacrylonitriles with 2-aminothiophenol
✍ Scribed by O. V. Shablykin; S. A. Chumachenko; V. S. Brovarets
- Book ID
- 111460696
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 193 KB
- Volume
- 80
- Category
- Article
- ISSN
- 1070-3632
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Available 2‐acylamino‐3,3‐dichloroacrylonitriles, when treated with hydrazine hydrate, provide 2‐alkyl‐ or 2‐aryl‐5‐hydrazino‐1,3‐oxazole‐4‐carbonitriles that readily add alkyl or aryl isothiocyanates and the adducts formed recyclize on heating. Finally, the synthesis results in 5‐alkyl
Readily available 2-acylamino-3,3dichloroacrylonitriles are sequentially treated with methyl mercaptoacetate in the presence of sodium methylate and with sulfuric acid to furnish the methyl ester of 7-amino-2-oxo-3H-thieno [2,3-b][1,4]thiazine-6-carboxylic acid. Treating it first with triethyl ortho