𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Re-localization ofActsk-1to mouse Chromosome 8, a new region of homology with human Chromosome 1

✍ Scribed by Serge Alonso; Xavier Montagutelli; Dominique Simon-Chazottes; Jean-Louis Guénet; Margaret Buckingham

Publisher
Springer-Verlag
Year
1993
Tongue
English
Weight
890 KB
Volume
4
Category
Article
ISSN
0938-8990

No coin nor oath required. For personal study only.

✦ Synopsis

We present here the genetic mapping of the o~-skeletal actin locus (Actsk-1) on mouse Chromosome (Chr) 8, on the basis of the PCR analysis of a microsatellite in an interspecific backcross. Linkage and genetic distances were established for four loci by analysis of 192 (or 222) meiotic events and indicated the following gene order: (centromere)-Es-l-11.7 cM-Tat-8.3 cM-Actsk-l-0.5 cM-Aprt. Mapping of ACTSK to human Chr 1 and of TAT and APRT to human Chr 16 demonstrates the existence of a new short region of homology between mouse Chr 8 and human Chr 1. Intermingling on this scale between human and mouse chromosomal homologies that occurred during evolution creates disorders in comparative linkage studies.

📜 SIMILAR VOLUMES

Genetic linkage studies in familial fron
Genetic linkage studies in familial frontal epilepsy: Exclusion of the human chromosome regions homologous to the El-1 mouse locus
✍ I. Lopes-Cendes; H.A. Phillips; I.E. Scheffer; J.C. Mulley; R. Desbiens; E. Ande 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 456 KB

Familial frontal epilepsy has been recently described in six pedigrees. All families reported show autosomal dominant inheritance with incomplete penetrance. Affected individuals develop predominantly nocturnal seizures with frontal lobe semiology. In 1959, a genetic mouse model for partial epilepsy

Localization of the 8;13 translocation b
Localization of the 8;13 translocation breakpoint associated with myeloproliferative disease to a 1.5 mbp region of chromosome 13
✍ Helena Kempski; Donald Macdonald; Antony J. Michalski; Terry Roberts; John M. Go 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 532 KB

There are five reported cases of an atypical myeloproliferative disorder in which the leukemia cells have a consistent t(8; I 3)(p I I ;q 12) tiranslocation. We analyzed the breakpoint in metaphases from two of these patients by fluorescence in situ hybridization using a series of yeast artificial c

Molecular mapping of chromosome 2 deleti
Molecular mapping of chromosome 2 deletions in murine radiation-induced AML localizes a putative tumor suppressor gene to a 1.0 cM region homologous to human chromosome segment 11p11–12
✍ Andrew Silver; John Moody; Rosemary Dunford; Debbie Clark; Sue Ganz; Robert Bulm 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 224 KB 👁 3 views

Radiation-induced acute myeloid leukemias (AMLs) in the mouse are characterized by chromosome 2 deletions. Previous studies showed that a minimal deleted region (mdr) of ϳ6.5 cM is lost from one homologue in chromosome 2-deleted AMLs. An AML tumor suppressor gene is proposed to map within this mdr.