Re-identification of Aspergillus nidulans wA gene to code for a polyketide synthase of naphthopyrone

✍ Scribed by Akira Watanabe; Isao Fujii; Ushio Sankawa; María E. Mayorga; William E. Timberlake; Yutaka Ebizuka

• Book ID: 104260672
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 249 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)80027-0

✦ Synopsis

By reconstruction and expression of the full-length WA (NWA) polyketide synthase ofA. nidulans based on the revised wA gene sequence, its product was re-identified to be a naphthopyrone compound YWA1 instead of citreoisocoumarin and its derivatives, which were found to be products of C-terminus truncated WA polyketide synthuse. YWA1 shows yellow color and is considered to be a true intermediate ofA. nidulans asexual spore pigments. Thus, the wA gene is identified to code for a polyketide synthase of heptaketide naphthopyrone YWA1.