Rationale for the development and current status of calcitriol in androgen-independent prostate cancer
β Scribed by Tomasz M. Beer; Anne Myrthue; Kristine M. Eilers
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- English
- Weight
- 177 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0724-4983
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Prostate cancer continues to challenge urologists in their daily clinical practice. The recent developments in diagnosis and therapy of this disease face them with an endless demand for earlier detection of the disease and better or more effective treatment. This is a logical consequence of the rapi
Development of androgen-independent prostatic cancer cells from androgen-responsive cells can occur by a variety of mechanisms (e.g., environmental adaptation, multifocal origin, or genetic instability). Regardless of the mechanism of development, however, once androgen-independent cancer cells beco
## Abstract ## BACKGROUND Coactivatorβassociated arginine methyltransferase 1 (CARM1) is a transcriptional coactivator of the androgen receptor (AR). It is involved in the regulation of the biologic functions of the AR. It remains to be determined whether CARM1 is involved in prostatic carcinogene