## Abstract Protein serine/threonine kinase casein kinase 2 (CK2) is a key player in cell growth and proliferation but is also a potent suppressor of apoptosis. CK2 has been found to be dysregulated in all the cancers that have been examined, including prostate cancer. Investigations of CK2 signali
Apoptosis: therapeutic significance in the treatment of androgen-dependent and androgen-independent prostate cancer
β Scribed by N. Kyprianou
- Publisher
- Springer-Verlag
- Year
- 1994
- Tongue
- English
- Weight
- 641 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0724-4983
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The vast majority of androgenβdependent prostate tumors progress toward incurable, androgenβindependent tumors. The identification of androgenβresponsive genes, which are still actively transcribed in the tumors of patients who have undergone androgen ablation, may shed light on the mol
## Abstract Anticancer drugs docetaxel and vinorelbine suppress cell growth by altering microtubule assembly and activating the proapoptotic signal pathway. Vinorelbine and docetaxel have been approved for treating several advanced cancers. However, their efficacy in the management of advanced horm
Development of androgen-independent prostatic cancer cells from androgen-responsive cells can occur by a variety of mechanisms (e.g., environmental adaptation, multifocal origin, or genetic instability). Regardless of the mechanism of development, however, once androgen-independent cancer cells beco
Androgen ablation-induced prostate cancer regression is transient and ends with the regrowth of androgen-independent (AI) tumors. To mimic this evolution in culture, we chronically deprived an androgen-dependent (AD) prostate cancer cell line (LNCaP) of androgen, generating an AI derivative which re
## BACKGROUND. Most prostate cancer cells respond to initial hormonal therapy; however, some of them eventually acquire resistance to the hormonal therapy. Hormone-independent prostate cancer usually exhibits resistance to chemotherapy and radiotherapy. Antioxidant systems are known to be involved