Rationale and experimental design for the va cooperative study of anticoagulation (warfarin) in the treatment of cancer
β Scribed by Leo R. Zacharski; William G. Henderson; Frederick R. Rickles; Walter B. Forman; C. J. Cornell Jr.; R. Jackson Forcier; Harold W. Harrower; Robert O. Johnson
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 964 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## BACKGROUND. The authors compared the relative efficacy and safety of lowβ molecularβweight heparin (LMWH) and unfractionated heparin (UFH) for the initial treatment of venous thromboembolism (VTE) between patients with and without cancer. ## METHODS. By using Cochrane methodology
## Abstract We investigated the therapeutic efficiency of sulfonateβmodified polyvinyl alcohol beads loaded with doxorubicin, irinotecan or mitoxantrone __in vitro__ and __in vivo__ in a model of experimental peritoneal carcinomatosis (PC). __In vitro__, cell proliferation was efficiently impaired
The three-arm clinical study including a placebo has been recommended to be the preferred study design for the comparison of an experimental treatment relative to a reference treatment. In a confirmatory three-arm study multiplicity issues arise that are not present in two-arm studies. In the past a