The p p ! 6INK4 and p I8 genes are members of the gene famil coding for inhibitors of cyclin-dependent kinases 4 and 6. frequently deleted in many human neoplasms. To examine the role of these 3 genes in lung carcinogenesis, somatic mutations within the genes were analyzed by single-strand conformat
Ratio of Expression of p16INK4ato p14ARFCorrelates with the Progression of Non-small Cell Lung Cancer
β Scribed by Moriyama, Satoru ;Nakashima, Yoshiaki ;Yano, Motoki ;Kaji, Masahiro ;Yamakawa, Yosuke ;Toyama, Tatsuya ;Yamashita, Hiroko ;Iwase, Hirotaka ;Sasaki, Hidefumi ;Saito, Yushi ;Kiriyama, Masanobu ;Kato, Jyoji ;Fujii, Yoshitaka
- Book ID
- 108582159
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2002
- Tongue
- English
- Weight
- 170 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0910-5050
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## Abstract Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during the etiopathogenesis of lung cancer and is a promising tool for cancer detection. In the present study, promoter hypermethylation of __p16^INK4A^__ and __CDH13__ genes was inv
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