Rate-limiting steps in oral absorption o
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Tugrul T. Kararli; James Stolzenbach
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Article
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1992
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John Wiley and Sons
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English
โ 415 KB
Oral administration of a leucotriene D4 antagonist drug (1) in the Beagle dog at doses of 2, 20, 100, 300, and 800 mg/kg resulted in dose-dependent bioavailability values (4-50%). To understand the dose dependence of the absorption of 1 in the dog, initial rates of absorption of 1, which were estima