Rate acceleration of phosphoric acid-catalyzed Diels-Alder reaction by internal hydrogen-bonding of adjacent hydroxy group

The formyl CH--O hydrogen bond as a cri

The formyl CH--O hydrogen bond as a critical factor in enantioselective reactions of aldehydes, part 4. Aldol, ethylation, hydrocyanation and Diels-Alder reactions catalyzed by chiral B, Ti and Al lewis acids

✍ E.J. Corey; David Barnes-Seeman; Thomas W. Lee 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 287 KB

Formyl C-H--O hydrogen bonding provides a rational explanation of several diverse catalytic enantioselective addition reactions of aldehydes, as outlined in Figures 12345.