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Rat tracheal organ culture supports replication of parainfluenza 1 (6/94) virus and promotes 6/94 virus rescue from latently infected human brain cells

✍ Scribed by Dr. Zofia Wroblewska; Mary Wellish; Lucy B. Rorke; Donald H. Gilden

Book ID
102378800
Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
491 KB
Volume
3
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Rat tracheal organ culture (TOC) supported replication of parainfluenza 1 (6/94) virus. Cell‐associated and cell‐free viruses were found after primary infection of TOC. In contrast to other mammalian systems, rat TOC was capable of maintaining 6/94 virus infectivity after primary infection. Rat TOC may be considered a potential indicator system that could be used to detect virus latent in human tissue.

📜 SIMILAR VOLUMES

Enhanced parainfluenza I (6/94) virus de
Enhanced parainfluenza I (6/94) virus detection in latently infected human brain cell cultures by treatment with cytochalasin D and dimethyl sulfoxide
✍ Zofia Wroblewska; Mary Wellish; Donald H. Gilden 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 506 KB

## Abstract The ability of cytochalasin D (CD) and dimethyl sulfoxide (DMSO) to enhance parainfluenza I (6/94) virus replication was studied in various cell culture systems. Treatment of CV~1~ cells with CD (1 μg/ml) dissolved in DMSO prior to primary 6/94 virus exposure at 10^0^–10^5^ multipliciti