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Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics

✍ Scribed by Martin, Jacob A.; Maris, Alexander S.; Ehtesham, Moneeb; Singer, Robert J.

Book ID
118269280
Publisher
MyJoVE Corporation
Year
2012
Tongue
English
Weight
163 KB
Volume
69
Category
Article
ISSN
1940-087X

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✍ Jeff W. M. Bulte; Martinus W. A. de Jonge; Richard L. Kamman; K. Gwan Go; Fred Z 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 653 KB

## Abstract Dextran‐magnetite particles (DMP) were studied for their use as a MR contrast agent to visualize lesions with a blood‐brain barrier (bbb) disruption. A freezing injury to the rat cerebral cortex was used as a model of bbb disruption. The biodistribution of iv‐injected DMP was studied us