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Rat liver-targeted naked plasmid DNA transfer by tail vein injection

โœ Scribed by Hiroki Maruyama; Noboru Higuchi; Shigemi Kameda; Jun-ichi Miyazaki; Fumitake Gejyo


Book ID
111640383
Publisher
Humana Press Inc
Year
2004
Tongue
English
Weight
228 KB
Volume
26
Category
Article
ISSN
1073-6085

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## Background: High levels of foreign gene expression in mouse hepatocytes can be achieved by rapid tail vein injection of a large volume of a naked dna solution, the 'hydrodynamics-based procedure'. rats are more tolerant of the frequent phlebotomies required for monitoring blood parameters than m