Homozygous deletion and loss of heterozygosity (LOH) at chromosome 3p21 have been observed in several types of human cancer including lung cancer and breast cancer. In previous work, we cloned and identified the human RAS association domain family 1A gene (RASSF1A) from the lung tumor suppressor loc
โฆ LIBER โฆ
RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours
โ Scribed by Astuti, Dewi; Agathanggelou, Angelo; Honorio, Sofia; Dallol, Ashraf; Martinsson, Tommy; Kogner, Per; Cummins, Carole; Neumann, Hartmut PH; Voutilainen, Raimo; Dahia, Patricia
- Book ID
- 110066200
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 178 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
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High frequency loss of 3p21.3 region where RASSF1A located was demonstrated in several tumors. We aimed to investigate the methylation status of RASSF1A and the frequency of LOH in 3p21.3 region in bladder cancer. Three bladder cancer cell lines, 40 cases of bladder TCC and 14 cases of paired voided