## Abstract In a mouse plasmacytoma S194, cโ__myc__ oncogene is rearranged with Ig gene by chromosomal translocation and consequently activated. We previously reported that transformation of phenotype and expression of rearranged cโ__myc__ were repressed in independently isolated hybrid clones, Iโ1
โฆ LIBER โฆ
Ras/MEK signaling suppresses Myc-dependent apoptosis in cells transformed by c-myc and activated ras
โ Scribed by Tsuneoka, Makoto; Mekada, Eisuke
- Book ID
- 110062594
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 568 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0950-9232
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The role of normal-cell-derived chromosome 15 in suppressing transformed phenotypes was studied in intraspecific hybrid clones between the c-myc oncogene activating BALBlc mouse plasmacytoma (S194) cells and normal spleen cells or fibroblasts from CBA/H-T6 mice. All the hybrid clones between S194 an