Rasagiline alone and in combination with riluzole prolongs survival in an ALS mouse model
β Scribed by Stefan Waibel; Alexander Reuter; Susanne Malessa; Eran Blaugrund; Albert C. Ludolph
- Book ID
- 106092528
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 302 KB
- Volume
- 251
- Category
- Article
- ISSN
- 0340-5354
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## Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with the death of motor neurons in the spinal cord and brainstem. The cause of ALS is unknown and there is no cure. This study demonstrates, for the first time, that vascular endothelial growth factor (V
Glutamate excitotoxicity has been suggested to contribute to the pathogenesis of Huntington's disease (HD). Riluzole is a substance with glutamate antagonistic properties that is used for neuroprotective treatment in amyotrophic lateral sclerosis and which is currently tested in clinical trials for