✦ LIBER ✦

Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS

✍ Scribed by Chengyun Zheng; Inger Nennesmo; Bengt Fadeel; Jan-Inge Henter

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 94 KB
Volume: 56
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.20223

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with the death of motor neurons in the spinal cord and brainstem. The cause of ALS is unknown and there is no cure. This study demonstrates, for the first time, that vascular endothelial growth factor (VEGF) delays progression of symptoms and prolongs survival in a Cu/Zn superoxide dismutase (SOD1) transgenic mouse model of ALS. These observations suggest that VEGF or related compounds, might be of value in the treatment of ALS patients. Ann Neurol 2004

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