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RAS oncogene activation induces proliferation in normal human thyroid epithelial cells without loss of differentiation

✍ Scribed by Gire, Véronique; Wynford-Thomas, David


Book ID
110062745
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
784 KB
Volume
19
Category
Article
ISSN
0950-9232

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## Abstract Spontaneously immortalized human mammary epithelial cells MCF‐IOA were transfected with an activated c‐Ha‐ras oncogene. Transfected cells (MCF‐IOT) acquire a malignant pheno‐type, as already reported. Studies of l‐2′‐deoxyuridine incorporation in cultures given graded doses of hydrocort