Ras activation revisited
β Scribed by Ignacio Rubio; Julian Downward
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 981 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1615-4053
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Point mutations in __ras__ genes have been found in a large number and wide variety of human tumors. These oncogenic Ras mutants are locked in an active GTPβbound state that leads to a constitutive and deregulated activation of Ras function. The dogma that __ras__ oncogenes are dominant
Wild-type ras has GTPase activity, and this activity is accelerated substantially by GTPase-activating proteins (GAPs). Oncogenic ras species have an abnormally low intrinsic GTPase activity, and this activity is insensitive to GAPs. We confirmed that the anti-ras monoclonal antibody Y13-238 inhibit