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Rare Variants Create Synthetic Genome-Wide Associations

✍ Scribed by Dickson, Samuel P.; Wang, Kai; Krantz, Ian; Hakonarson, Hakon; Goldstein, David B.; Hastie, Nicholas

Book ID: 119988383
Publisher: Public Library of Science
Year: 2010
Tongue: English
Weight: 477 KB
Volume: 8
Category: Article
ISSN: 1544-9173
DOI: 10.1371/journal.pbio.1000294

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## Abstract The phenomenon of synthetic association raises the possibility that common variant genetic markers may be coupled with functional rare variants sufficiently often to allow the rare variants to be tagged by the common ones. Using human exome sequence data from the 1000 Genomes Project, t