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Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

✍ Scribed by Johansen, Christopher T; Wang, Jian; Lanktree, Matthew B; Cao, Henian; McIntyre, Adam D; Ban, Matthew R; Martins, Rebecca A; Kennedy, Brooke A; Hassell, Reina G; Visser, Maartje E


Book ID
109914634
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
302 KB
Volume
42
Category
Article
ISSN
1061-4036

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## Abstract In this paper we investigate the power to identify gene Γ— gene interactions in genome‐wide association studies. In our analysis we focus on two‐stage analyses: analyses in which we only test for interactions between single nucleotide polymorphisms that show some marginal effect. We give