Rapid turnover of T cells in acute infectious mononucleosis
✍ Scribed by Derek C. Macallan; Diana L. Wallace; Andrew J. Irvine; Becca Asquith; Andrew Worth; Hala Ghattas; Yan Zhang; George E. Griffin; David F. Tough; Peter C. Beverley
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 248 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0014-2980
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We examined the patterns of viral gene expression in acute infectious mononucleosis (IM) patients and the clonality of the directly growing EBV-carrying cell lines. Both low- and high-density EBV-carrying B cells obtained from the patients' tonsils expressed EBNA1, EBNA2 and LMP1. Like LCLs and immu
## Abstract EBNA‐positive lymphoblast cells were detected in 0.1 to 0.9% of the T‐cell‐depleted lymphocytes obtained from peripheral blood samples of five patients with infectious mononucleosis (IM). The same blood specimens from four of the five patients contained cells that formed EBNA‐positive c
## Abstract After removal of SRBC rosette‐forming T‐cells from the peripheral blood, the residual, largely B‐lymphocyte fractin of five infectious mononucleosis patients was found no contain 0.5‐2% blast cells, positive for the EBV‐determined nuclear antigen (EBNA). There was a rough parallelism be
## Abstract Sera from infectious mononucleosis patients aged 2 to 35 years and from normal subjects aged 11 to 35 years were examined for the presence of antibody to the EB virus capsid antigen (VCA) in the indirect immunofluorescence test, and for the presence of antibody reactive with the soluble