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EBV-determined nuclear antigen (EBNA)-positive cells in the peripheral blood of infectious mononucleosis patients

✍ Scribed by George Klein; Erick Svedmyr; Mikael Jondal; Per Olof Persson

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
482 KB
Volume
17
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

After removal of SRBC rosette‐forming T‐cells from the peripheral blood, the residual, largely B‐lymphocyte fractin of five infectious mononucleosis patients was found no contain 0.5‐2% blast cells, positive for the EBV‐determined nuclear antigen (EBNA). There was a rough parallelism between the presence of large lymphoblasts in the hematological smear, EBNA‐positive large blasts in the B‐cell fraction and the ability of the T‐cell fraction to expert an EBV‐specific lymphocytotoxicity on established cell lines in vitro. EBNA‐positive B‐cells and EBV‐specific killer T‐cells disappeared after the acute phase of the disease.

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