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Rapid Treadmilling of Brain Microtubules Free of Microtubule-Associated Proteins in vitro and Its Suppression by Tau

✍ Scribed by Dulal Panda, Herbert P. Miller and Leslie Wilson


Book ID
123642315
Publisher
National Academy of Sciences
Year
1999
Tongue
English
Weight
979 KB
Volume
96
Category
Article
ISSN
0027-8424

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## Abstract Phosphorylation of tau protein has been suggested as a major mechanism regulating its functions. In assembled brain microtubules, tau is phosphorylated, but additional phosphorylation can be induced in vitro. Supply of excess ATP alone was sufficient to reduce migration of tau on SDS ge