Rapid T1 mapping of mouse myocardium with saturation recovery look-locker method

✍ Scribed by Wen Li; Mark Griswold; Xin Yu

• Book ID: 102534008
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 475 KB
• Volume: 64
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.22544

✦ Synopsis

Abstract

Dynamic contrast‐enhanced MRI using gadolinium or manganese provides unique characterization of myocardium and its pathology. In this study, an electrocardiography (ECG) triggered saturation recovery Look‐Locker method was developed and validated for fast cardiac T~1~ mapping in small animal models. By sampling the initial portion of the longitudinal magnetization recovery curve, high temporal resolution (∼3 min) can be achieved at a high spatial resolution (195 × 390 μm2) in mouse heart without the aid of parallel imaging or echo‐planar imaging. Validation studies were performed both in vitro on a phantom and in vivo on C57BL/6 mice (n = 6). Our results showed a strong agreement between T~1~ measured by saturation recovery Look‐Locker and by the standard saturation recovery method in vitro or inversion recovery Look‐Locker in vivo. The utility of saturation recovery Look‐Locker in dynamic contrast‐enhanced MRI studies was demonstrated in manganese‐enhanced MRI experiments in mice. Our results suggest that saturation recovery Look‐Locker can provide rapid and accurate cardiac T~1~ mapping for studies using small animal models. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.