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Rapid Synthesis of Functionalized Indenes, Triazoles, and Glucocorticoid Receptor Modulators by Sequential Multicatalysis Cascade Reactions

✍ Scribed by Dhevalapally B. Ramachary; Rumpa Mondal; Chintalapudi Venkaiah

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
230 KB
Volume
2010
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

A general process for the synthesis of substituted indenes and 1,2,3‐triazoles was achieved for the first time through a multicatalysis cascade reaction of 2‐ethynylbenzaldehydes, CH acids, organic hydrides, and azides in the presence of a catalytic amount of L‐proline/CuI/DIPEA. In this communication, we discovered the utilization of a single copper catalyst for two different reactions and shown synthetic application to the high‐yielding synthesis of glucocorticoid receptor modulators.

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ChemInform Abstract: Rapid Synthesis of
ChemInform Abstract: Rapid Synthesis of Functionalized Indenes, Triazoles, and Glucocorticoid Receptor Modulators by Sequential Multicatalysis Cascade Reactions.
✍ Dhevalapally B. Ramachary; Rumpa Mondal; Chintalapudi Venkaiah 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 69 KB 👁 1 views

## Abstract The iminium activation of aldehydes, the self‐activation of olefins, and the simultaneous activation of metal ion alkynes are combined in a cascade sequence, constituting a new carbocyclization method to furnish indenes through a Conia‐ene reaction, and a new heterocyclization method to