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ChemInform Abstract: Rapid Synthesis of Functionalized Indenes, Triazoles, and Glucocorticoid Receptor Modulators by Sequential Multicatalysis Cascade Reactions.

✍ Scribed by Dhevalapally B. Ramachary; Rumpa Mondal; Chintalapudi Venkaiah

Publisher
John Wiley and Sons
Year
2010
Weight
69 KB
Volume
41
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

The iminium activation of aldehydes, the self‐activation of olefins, and the simultaneous activation of metal ion alkynes are combined in a cascade sequence, constituting a new carbocyclization method to furnish indenes through a Conia‐ene reaction, and a new heterocyclization method to furnish 1,2,3‐triazoles through [3+2] cycloaddition.

📜 SIMILAR VOLUMES

Rapid Synthesis of Functionalized Indene
Rapid Synthesis of Functionalized Indenes, Triazoles, and Glucocorticoid Receptor Modulators by Sequential Multicatalysis Cascade Reactions
✍ Dhevalapally B. Ramachary; Rumpa Mondal; Chintalapudi Venkaiah 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB

## Abstract A general process for the synthesis of substituted indenes and 1,2,3‐triazoles was achieved for the first time through a multicatalysis cascade reaction of 2‐ethynylbenzaldehydes, CH acids, organic hydrides, and azides in the presence of a catalytic amount of L‐proline/CuI/DIPEA. In thi