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Rapid solid-state analysis of freeze-dried protein formulations using NIR and Raman spectroscopies

✍ Scribed by Holger Grohganz; Delphine Gildemyn; Erik Skibsted; James M. Flink; Jukka Rantanen


Book ID
102394695
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
209 KB
Volume
100
Category
Article
ISSN
0022-3549

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The purpose of this study was to explore why changes in the molecular mobility associated with glass transition, the timescale of which is on the order of 100 s, can be detected by measuring the nuclear magnetic resonance relaxation times that reflect molecular motions on the order of 10 kHz and 1 M