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Rapid sequence evolution of the mammalian sex-determining gene SRY

✍ Scribed by Whitfield, L. Simon; Lovell-Badge, Robin; Goodfellow, Peter N.


Book ID
109785022
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
392 KB
Volume
364
Category
Article
ISSN
0028-0836

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The sex-determining gene SRY was screened for molecular alteration in an XY sex-reversed female by single-strand conformation polymorphism (SSCP) technique. An A-to-G transition was detected which leads to an exchange of a tyrosine by a cysteine in the SRY protein. The affected tyrosine residue loca