Rapid sequence evolution of the mammalian sex-determining gene SRY
β Scribed by Whitfield, L. Simon; Lovell-Badge, Robin; Goodfellow, Peter N.
- Book ID
- 109785022
- Publisher
- Nature Publishing Group
- Year
- 1993
- Tongue
- English
- Weight
- 392 KB
- Volume
- 364
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/364713a0
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In mammals, testis determination is under the control of the testis-determining factor borne by the Y chromosome. SRY, a gene cloned from the sex-determining region of the human Y chromosome, has been equated with the testis-determining factor in man and mouse. We have used a human SRY probe to iden
In mammals, male sex determination, as well as spermatogenesis, is controlled by genes on the Y chromosome. Evolutionary comparisons may be used to detect and test candidate genes for these functions, under the hypothesis that the rapid evolution of the mammalian Y chromosome causes it to contain fe
The sex-determining gene SRY was screened for molecular alteration in an XY sex-reversed female by single-strand conformation polymorphism (SSCP) technique. An A-to-G transition was detected which leads to an exchange of a tyrosine by a cysteine in the SRY protein. The affected tyrosine residue loca