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Rapid screening of destruxins by liquid chromatography/mass spectrometry

✍ Scribed by Jegorov, Alexandr; Havlíček, Vladimír; Sedmera, Petr

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
371 KB
Volume
33
Category
Article
ISSN
1076-5174

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✦ Synopsis

A liquid chromatographic/mass spectrometric (LC/MS) method utilizing an atmospheric pressure chemical ionization (APCI) interface and in-source collisionally induced dissociation (CID) was developed for the rapid screening of the cyclic hexadepsipeptides destruxins, produced by the fungi Metarhizium anisopliae and Trichothecium roseum. The APCI mass spectra are fully consistent with the high-energy CID data but the sequence ions are abundant over the whole mass range. In addition to 22 known destruxins, two new representatives of this family were detected by LC/MS analysis : destruxin and roseotoxin A were isolated and their structures were inferred Ed 1 from MS/MS and NMR data.

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