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Rapid removal of protecting groups from peptides by catalytic transfer hydrogenation with 1,4-cyclohexadiene

โœ Scribed by Felix, Arthur M.; Heimer, Edgar P.; Lambros, Theodore J.; Tzougraki, Chryssa; Meienhofer, Johannes


Book ID
111913603
Publisher
American Chemical Society
Year
1978
Tongue
English
Weight
371 KB
Volume
43
Category
Article
ISSN
0022-3263

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A rapid non-acidolytic method for deprot
โœ Mohmed K. Anwer; Arno F. Spatola ๐Ÿ“‚ Article ๐Ÿ“… 1981 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 227 KB

Ammonium for-mate aided catalytic transfer hydrogenation has been employed in the cleavage, and concommitant deprotection, of the pentapeptide leucine enkephalin from the Merrifield peptide resin under ambient conditions of temperature and pressure in a neutral medium.