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Rapid radiochemical and chemical quality control of [11C]putrescine

✍ Scribed by S.J. Gatley; R.A. Ferrieri; J.S. Fowler; R.R. Macgregor; A.P. Wolf

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 274 KB
Volume: 44
Category: Article
ISSN: 0969-8043
DOI: 10.1016/0969-8043(93)90146-2

No coin nor oath required. For personal study only.

✦ Synopsis

A short (4.6 x 50 mm) cation exchange column was used in conjunction with conductivity and radioactivity detectors to determine the radiochemical purity (> 99%) and specific radioactivity (0.5-1.0 Ci/mu mol) of [1-11C]putrescine prepared via Michael addition of [11C]cyanide to acrylonitrile. The absence of acrylonitrile, a rodent carcinogen, from the final preparation was verified at the 50 ng level capillary vapor-phase chromatography (VPC) using a nitrogen-phosphorus detector. Routine VPC analysis using a Poropak Q column and flame ionization detection showed that preparations contained no more than 1 microgram of acrylonitrile.

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