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Quality control procedures in the preparation of 2-deoxy-D-[1-11C] glucose radiopharmaceutical

✍ Scribed by Manhar M. Vora; Thomas E. Boothe; Ronald D. Finn; Patricia M. Smith; Albert J. Gilson

Publisher: John Wiley and Sons
Year: 1983
Tongue: French
Weight: 401 KB
Volume: 20
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580200310

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✦ Synopsis

Preparation and quality control of 2-de0xy-D[l-~~CI glucose ( C-ZDG, L)

have been accomplished by a ccmbkation of cation-exchange and high performance liquid chrcmtography (HPIC) to give the radiopharmceutical i n greater than 99% radiochemical purity and an w & a l l 25-35% radiochemicdl yield i n 45-50 min. Quality control procedures utilizing Gc and H P K have been developed to determine not only chemical and radiochemical purity of the f i n a l product, but also t o examine the reactants used and the products formed during the preparation of 1. 11 Key wrds: 2-deoxy-D-[1-Clglucose, quality control, positron emission tmcgraphy(PFT), 18-crm-6, preparative I-JPX.

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