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ChemInform Abstract: Nucleic-Acid Analogues with Constraint Conformational Flexibility in the Sugar—Phosphate Backbone ′Tricyclo-DNA′. Part 1. Preparation of [(5′R,6′R)-2′-Deoxy-3′,5′-ethano-5′,6′-methano-β-D-ribofuranosyl] thymine and -adenine, and the Corresponding Phosphoramidites for Oligonucleotide Synthesis.

✍ Scribed by R. STEFFENS; C. LEUMANN

Publisher: John Wiley and Sons
Year: 2010
Weight: 39 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199809221

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✦ Synopsis

Nucleic-Acid Analogues with Constraint Conformational Flexibility in the Sugar-Phosphate Backbone 'Tricyclo-DNA'. Part 1. Preparation of [(5'R,6'R)-2'-Deoxy-3',5'-ethano-5',6'-methano-β-D-ribofuranosyl] thymine and -adenine, and the Corresponding Phosphoramidites for Oligonucleotide Synthesis.

-An efficient synthesis of the tricyclonucleosides (VIII) and (IX) containing the bases adenine and thymine as well as that of building blocks (X) for oligonucleotide preparation is described. -

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